1401: Japan re-enters into a tributary relationship with Ming Dynasty China

1404  Born February 9 - Constantine XI, last Byzantine Emperor

1405: Chinese fleet commander Zheng He sets sail to explore the world for the first time.

1405: First written record of whiskey being consumed recorded in Ireland, where it was distilled by Catholic monks

1447: The first European movable type printing process by Johannes Gutenberg

1453: The conquest of Constantinople by the Ottomans

1492, Spain: European voyage to the Americas by Columbus

1492  End of the Reconquista, the final expulsion of the Moors from the Iberian Peninsula

1492;  Spanish government expels the Jews.

1498 Vasco de Gama  first voiage to India traveling around Africa.  

1509 Catherane and Henry  Vll  married

1513: First formulation of modern politics with the publication of Machiavelli's The Prince

1517: The Reformation ,Martin Luther nailing his ninety-five theses to the door of the church in Wittenberg, Germany.

1520 Aztecs defeated

1520 Magallanes cercumnavigates the world

1522 Loyaola has conversion at benedictine monastery

1536: Catherine of Arrigone is killed

1541: John Calvin moves to Genieva

1545-63: The Council of Trent marks the end of the medieval Roman Catholic Church.